Aloe - Analytical Research
Antimetastatic Properties Of Aloe Juice
Gribel’ NV; Pashinskii VG
Vopr Onkol 32(12):38-40 1986
An evaluation of antimetastatic properties of succus Aloes was carried out using three types of experimental tumors of mice and rats. It was found that succus Aloes treatment contributes to reduction of tumor mass, metastatic foci and metastasis frequency at different stages of tumor progress without affecting major tumor growth. Succus Aloes potentiates the anti-tumor effect of 5-fluorouracil and cyclophosphamide as components of combination chemotherapy.
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Effects Of Aloe Extracts On Human Normal & Tumor Cells In-Vitro
Winters WD; Benavides R; Clouse WJ
Dep. Microbiol., Univ. Tex. Health Sci. Center
Econ Bot 35 (1), 1981, 89-95
Fractions of leaf extracts from 2 local types, labeled Aloe vera (subsequently identified as A. barbadensis Mill., and A. saponaria Haw.), were prepared by differential centrifugation and tested by in vitro assays for the presence of lectin-like activities and for effects on the attachment and growth of human normal and tumor cells.
Epidemiologic Survey On Lung Cancer With Respect To Cigarette Smoking & Plant Diet
Sakai R
Department Of Epidemiology, School Of Health Sciences, Ryukyu University
Jpn J Cancer Res 80(6):513-20 1989 Jun
This case-control study of lung cancer was based on a cross-sectional questionnaire survey of inpatients at 5 general hospitals in Okinawa, Japan, from 1982 to 1987.
The purpose of the study was to clarify the relations of lung cancer to cigarette smoking and plant diet. Ingestion frequencies of 17 major dietary plants and/or herbs were obtained by means of a questionnaire interview. As eligible subjects for a case-control analysis, there were 673 respondents aged over 30 years with clear smoking history, age, sex and diagnosis. Psychiatric patients were excluded.
Various AIDS studies were completed by researchers such as Dr. Terry Pulse, M.D., Dr. Reg McDaniel, M.D., Dr. Terry Watson, D.O., Dr. Clumeck, M.D. (of Belgium) and others throughout the 1980’s using oral mucopolysaccharides.
The results were impressive, demonstrating in many of the studies an average of 70% improvement in symptoms and laboratory criteria within 3 to 4 months. Many patients stated that opportunistic infections had stopped and they were able to return to normal activity.
In one dramatic case, a man with advanced AIDS had 17 liver tumors and after one and a half years on oral Aloe mucopolysaccharides, his T-Cell count was normal and all the tumors had disolved (confirmed by x-ray films).
Source: J Pharm Sci 1982 Jul;71(7):739-41
Title: Cardiac stimulant action of constituents of Aloe saponaria.
Authors: Yagi A, Shibata S, Nishioka I, Iwadare S, Ishida Y.
Abstract: A highly potent cardiotonic substance, calcium isocitrate, was isolated from Aloe saponaria, using solvent partition, nonionic porous resin, and gel permation chromatographies. Cardiac stimulant activity of synthesized stereoisimers of calcium isocitrate was demonstrated in isolated guinea pig atria. PMID: 7120054 [PubMed - indexed for MEDLINE]
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Source: J Pharm Sci 1982 Oct;71(10):1172-4
Title: Antibradykinin active material in Aloe saponaria.
Authors: Yagi A, Harada N, Yamada H, Iwadare S, Nishioka I.
Abstract: A material having antibradykinin activity on isolated guinea pig ileum was partially purified from the nondialysate of the pulp of Aloe saponaria by repetition of gel chromatography using a hydrophilic polyvinyl gel and dextran gels. From the results of amino acid and carbohydrate analyses, the antibradykinin-active material was estimated to be a glycoprotein. It was found that this material catalyzes the hydrolysis of bradykinin at pH 7.4. The results of peptide analysis using reversed-phase high-performance liquid chromatography coupled with amino acid analysis indicate that this glycoprotein cleaves the Gly4-Phe5 and Pro7-Phe8 bonds of the bradykinin molecule. PMID: 7143219 [PubMed - indexed for MEDLINE]
Source: J Pharm Sci 1984 Jan;73(1):62-5
Title: Structure determination of polysaccharides in Aloe saponaria (Hill.) Haw. (Liliaceae).
Authors: Yagi A, Hamada K, Mihashi K, Harada N, Nishioka I.
Abstract: Neutral polysaccharides that inhibit carrageenin-induced edema in rats were isolated from the nondialysate of the pulp of Aloe saponaria by gel filtration. These were shown to be a linear polymer of a 1,4-linked beta-D-mannopyranose (mol. wt. 15,000) containing 18% acetyl groups (As mannan 1), and a 1,4-linked alpha-D-mannopyranose polymer containing a single branch on the principal chain consisting of D-glucose residues linked at C-2 and C-4 (mol. wt. 66,000), with 10% acetyl groups (As mannan 2). As mannan 1 inhibited carrageenin-induced hind paw edema at 50 mg/kg ip in rats; As mannan 2 was not tested for pharmacological activity. A crude preparation of both As mannans was effective when given intraperitoneally, but was ineffective when given orally. PMID: 6694085 [PubMed - indexed for MEDLINE]
International Immunopharmacology
Volume 4, Issue 3 , March 2004, Pages 411-418
Mannan from Aloe saponaria inhibits tumoral cell activation and proliferation
M. Cecilia Sampedro a, Rodolfo L. Artola b, Mariano Murature c, Domingo Murature b, Yanina Ditamo a, German A. Roth a and Silvia Kivatinitz a.
a Departamento de Química Biológica-CIQUIBIC, Facultad Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, C5000GYA-, Córdoba 5016, Argentina
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